Table 1. Epitope specificity and neutralizing activity of IgG HCMV-gB specific antibodies.
| epitope specificity | ||||||||||||
| AD-1 | AD-2 | Dom II/AD-4 | Dom I/AD-5 | unknown | ||||||||
| Donor | numbera | nt b (%) | totalb (%) | ntc (%) | total b (%) | ntc (%) | totalb (%) | ntc (%) | totalb (%) | ntc (%) | totalb (%) | ntc (%) |
| AB | 78 | 3 | 43 | 0 | 0 | 0 | 0 | 0 | 3 | 100 | 54 | 0 |
| SA | 34 | 0 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 74 | 0 |
| JN | 72 | 1 | 42 | 0 | 1 | 0 | 0 | 0 | 1 | 100 | 56 | 0 |
| TJ | 92 | 0 | 58 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 40 | 0 |
| NT | 250 | 11 | 14 | 5 | 0 | 0 | 25 | 87d | 18 | 100 e | 43 | 0 |
| TW | 124 | 5 | 56 | 6 | 0 | 0 | 2 | 100 | 0 | 0 | 42 | 0 |
| TS | 238 | 2 | 28 | 3 | 1 | 0 | 14 | 100f | 3 | 100g | 54 | 0 |
| mean, (range) | 127 (34–250) | 3.1 (0–11) | 38.1 (14–56) | 2.0 (0–6) | 0.6 (0–2) | 0 | 5.9 (0–25) | 95.7 (87–100) | 100 | 51.9 (40–74) | 0 | |
a
total number of gB specific clones analyzed.
b
% of all clones.
c
percentage of epitope specific clones with 50% neutralization at concentrations of 3 µg or less. Every antibody was tested at least twice with similar results.
d
13 of 15 clones that could be tested.
e
12 of 45 clones that could be tested.
f
1 of 34 clones that could be tested.
g
1 of 7 clones that could be tested.