Table 1.
Patient demographics and outcome
| Pt | Sex/age | Differentiation | TNM (stage) | Surgical Resection | Chemotherapy | Radiotherapy | Failure (mo) | Definitive Treatment of recurrence | Follow-up (mo) |
|---|---|---|---|---|---|---|---|---|---|
| 1 | M/22 | mod | T4aN0M0 (IVA) | ND, MM, mandibulectomy | none | AdRT | none | none | NED (166) |
| 2 | F/67 | mod | T4aN2bM0 (IVA) | CFR, R ND (I-III) | NAC | AdRT | dural metastases (21) | none | DOD (56.2) |
| 3 | F/43 | mod | T1N0M0 (I) | SPH, ETH | none | AdRT | none | none | NED (31.3) |
| 4 | M/46 | mod | T4bN1M0 (IVb) | none | NAC | CRT | none | none | NED (16.6) |
| 5 | M/54 | mod | T4N0M0 (IV) | STR ES | Concurrent | AdCRT | Bilateral cervical LN (46) | ND, AdRT | NED (107) |
| 6 | M/47 | mod | T4bN0M0 (IVB) | STR CFR | none | AdRT | Ipsilateral level I (125) | ND, AdCRT | NED (172) |
| 7 | M/54 | mod | TxN0M0 | S | AdC | AdRT | local (80) | NAC/RT/AdC, CFR | DOD (119) |
| 8 | M/78 | poorly | T4bN0M0 (IVB) | S | none | none | none | none | NED/Dead (77) |
| 9 | F/24 | poorly | T4bN0M0 (IVB) | none | NAC; AdC | RT | none | none | NED (136) |
| 10 | F/47 | poorly | T4bN1M0 (IVB) | none | NAC | RT | leptomeningeal dz (4.1) | none | DOD (13) |
| 11 | F/38 | poorly | T4bN0M0 (IVB) | CFR | none | AdRT | none | none | NED (47.5) |
| 12 | M/53 | poorly | TxN0M0 | STR ETH | AdC; concurrent | AdCRT | none | none | NED (17.8) |
| 13 | M/51 | poorly | T3N0M0 (III) | none | NAC; AdC | RT | persistent (0) | none | DOD (17) |
| 14 | F/57 | poorly | T4aN0M0 (IVA) | CFR, SPH | NAC | none | none | none | DOC (16) |
| 15 | M/70 | poorly | T4bN0M0 (IVB) | STR ETH | AdC | none | persistent (0) | CFR/RT | DOD (16) |
| 16 | F/33 | poorly | T2N0M0 (II) | CFR | none | AdRT | Ipsilateral levels I-V (5) |
ND, AdRT | NED (149) |
| 17 | M/38 | poorly | T2N0M0 (II) | none | NAC | RT | local (11) | ETH/MM/SPH, AdCRT | DOD (37.5) |
| 18 | F/60 | poorly | T4bN0M0 (IVB) | STR CFR | AdC | AdRT | persistent (0) | AdC | NED/Dead (112) |
| 19 | F/38 | poorly | T4aN0M0 (IVA) | CFR | none | AdRT | none | none | NED (168) |
| 20 | M/64 | poorly | T4bN0M0 (IVB) | STR CFR | Concurrent | AdCRT | none | none | NED (63) |
AWD = alive with disease; NED = no evidence of disease; DOD = dead of disease; DOC = dead of treatment complications. S = resection of unknown type, RT = radiation therapy, AdRT = adjuvant radiation therapy, NAC = neoadjuvant chemotherapy, AdC = adjuvant chemotherapy, AdCRT = adjuvant chemoradiation. CFR = Craniofacial Resection, ETH = Ethmoidectomy, SPH = Sphenoidectomy, MM = Medial Maxillectomy, STR = Subtotal Resection.