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. 2011 Aug 15;22(16):2797–2809. doi: 10.1091/mbc.E11-02-0137

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© 2011 Matsumura et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 4: — Hsc70 binding cycle has a dominant and essential role in CFTR degradation. (A) CFTR was synthesized in the presence of 10 μM CBag and subjected to an in vitro degradation assay without CBag. The percentage of CFTR degraded into TCA-soluble fragments at each point is shown. (B) CFTR was synthesized in the absence of CBag and subjected to an in vitro degradation assay with 20 μM CBag. (C) CFTR was synthesized in the presence of 10 μM CBag and subjected to an in vitro degradation assay in the presence of 20 μM CBag. In (B) and (C), result without CBag in translation and degradation (from A) is shown as broken line for comparison. Data show mean ± SEM (n = 4–5).