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. 2011 Aug 15;22(16):2886–2899. doi: 10.1091/mbc.E10-10-0862

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© 2011 Bernadskaya et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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Figure 4: — Apical enrichment of F-actin in the embryonic intestine requires the WAVE/SCAR complex, ERM-1, and the DLG-1/AJM-1 complex but not the cadherin/catenin complex. Embryos were stained with phalloidin to visualize F-actin (green) accumulation in the apical intestine in wild type and in embryos depleted of candidate regulators of apical morphogenesis. DAPI (red) labels nuclei. The apical region of the intestine (yellow rectangle) is amplified below each micrograph. Embryos at 550 min after first cleavage were compared. Actin regulators, including WAVE/SCAR components wsp-1, and arp-2, are shown. Double mutants were made by feeding RNAi for one gene to a strain carrying a genetic mutation in a second gene. RNAi effectiveness was verified by phenotypic assays. n ≥ 10 embryos for each genotype. Error bars show SEM. Asterisks indicate statistical significance, p < 0.05.