Figure 4. Comparison of Isyna1 methylation profiles between male and female rat brain cortex.
Details are the same as in Figure 1. Methylation levels were relatively higher in region 1 in the male compared with the female, with no significant differences in regions 2 or 3. The male brain cortex also harbored two significantly methylated CpG residues (asterisks) at CpG8 and CpG103 (each 30%). CpGs31 and 70, although highly methylated, exhibited no major sex-specific differences. The CpG profile for the male brain cortex is derived from Figure 1.
F: Female; M: Male; MMI: Mean methylation index; Nt: Nucleotide; Str: Structure.