Table 2.
Distribution of methylated CpG residues in Isyna1.
| Tissue | Total methylated sites† |
Region 1 | Region 2 | Region 3 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total |
Significant sites‡ |
MMI | Total |
Significant sites |
MMI | Total |
Significant sites |
MMI | ||
| Brain M§ | 16 | 6 | CpG8 | 12.2 | 6 | CpG31, 70 | 4.9 | 4 | CpG103 | 5.5 |
| Brain F§ | 11 | 3 | 3.0 | 3 | CpG31, 70 | 4.5 | 5 | 5.5 | ||
| Heart | 8 | 1 | 1.1 | 6 | CpG31, 45, 70 | 5.5 | 1 | 1.8 | ||
| Pancreas | 7 | 0 | 0 | 4 | CpG31, 45, 70 | 5.0 | 3 | 3.6 | ||
| Spleen | 16 | 3 | 4.4 | 4 | CpG31, 45, 70 | 4.8 | 7¶ | CpG96, 103, 105, 106 | 18.2 | |
| Testis | 6 | 1 | 1.1 | 4 | CpG31, 45, 70 | 4.9 | 1 | 1.0 | ||
†
Number of methylated CpG sites identified in the analyzed 1.35-kb region: regions 1–3.
‡
CpG residues with ≥30% methylation.
§
Brain cortex.
¶
Nine CpGs, if the longer amplicon is considered (see Figure 1).
F: Female; M: Male; MMI: Mean methylation index.