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. 2011 Aug 11;6(8):e22880. doi: 10.1371/journal.pone.0022880

Figure 4. Alternative splicing of c-myb transcripts in normal and leukemic cells.

Figure 4

(A) Rates of c-myb alternative splicing in normal cells and leukemias. Polony assays were used to measure the levels of normal and alternatively spliced c-myb transcripts in normal CD34+ progenitors from healthy donors (n = 3) or in pediatric precursor B-ALL patient samples (n = 13). The black and gray sections of each bar indicate the fractions of alternatively spliced or wild type transcripts, respectively. (B) Patterns of c-myb alternative splicing in pediatric precursor B-ALL samples. Dots indicate levels of wt or splice variant expression, as a fraction of total c-myb transcripts detected, as determined by polony assay for pediatric precursor B-ALL samples (n = 13, filled circles) or CD34+ cells from normal donors (n = 3, empty diamonds). Each symbol represents the average of duplicate measurements and the horizontal bars represent the median values for the leukemia samples.