Table 1. Retinal Nerve Fiber Layer Thicknesses and Total Macular Volume Among Cirrus HD-OCT vs. Stratus Study Participants.
| Stratus OCT | Cirrus-HD OCT | r | P value | Mean Difference (95% CI) | Lower LOA (95% CI) | Upper LOA (95% CI) | Range | |
| RNFL Thickness* | ||||||||
| All Participants (n = 229) | 95.7±15.9 | 88.3±13.8 | 0.93 | <0.001 | 7.4 (6.7 to 8.2) | −4.1 (−5.4 to −2.8) | 18.9 (17.6 to 20.2) | 23.00 |
| RRMS (n = 138) | 92.8±16.0 | 85.7±14.3 | 0.93 | <0.001 | 7.1 (6.1 to 8.1) | −4.4 (−6.1 to −2.7) | 18.6 (16.9 to 20.3) | 23.04 |
| Progressive MS (n = 22) | 88.5±15.9 | 82.8±12.0 | 0.93 | <0.001 | 5.7 (2.9 to 8.5) | −7.0 (−11.6 to −2.3) | 18.3 (13.7 to 23.0) | 25.30 |
| Healthy Controls (n = 69) | 103.9±12.1 | 95.3±10.3 | 0.90 | <0.001 | 8.7 (7.4 to 9.9) | −2.1 (−4.4 to 0.1) | 19.4 (17.2 to 21.8) | 21.52 |
| TMV** | ||||||||
| All Participants (n = 229) | 6.63±0.45 | 7.93±0.47 | 0.95 | <0.001 | −1.30 (−1.31 to −1.28) | −1.59 (−1.62 to −1.59) | −1.01 (−1.04 to −0.98) | 0.58 |
| RRMS (n = 138) | 6.53±0.5 | 7.82±0.47 | 0.95 | <0.001 | −1.29 (−1.32 to −1.27) | −1.59 (−1.63 to −1.55) | −0.99 (−1.03 to −0.95) | 0.60 |
| Progressive MS (n = 22) | 6.41±0.36 | 7.75±0.38 | 0.95 | <0.001 | −1.34 (−1.39 to −1.29) | −1.58 (−1.66 to −1.50) | −1.10 (−1.18 to −1.02) | 0.48 |
| Healthy Controls (n = 69) | 6.89±0.35 | 8.20±0.37 | 0.93 | <0.001 | −1.31 (−1.34 to −1.27) | −1.59 (−1.65 to −1.53) | −1.03 (−1.09 to −0.97) | 0.56 |
Abbreviations: OCT: Optical coherence tomography; RNFL: Retinal nerve fiber layer; RRMS: Relapsing remitting multiple sclerosis; MS: Multiple sclerosis; TMV: Total macular volume; CI: confidence interval; LOA: limit of agreement.
*All measurements are in µm.
**All measurements are in mm3.