Table 2. Retinal Nerve Fiber Layer Thicknesses and Total Macular Volume Among Cirrus HD-OCT vs. Spectralis Study Participants.
| Cirrus-HD OCT | Spectralis SD-OCT | r | P value | Mean Difference (95% CI) | Lower LOA (95% CI) | Upper LOA (95% CI) | Range | |
| RNFL Thickness* | ||||||||
| All Participants (n = 95) | 90.6±12.0 | 92.6±13.6 | 0.96 | <0.001 | 1.94 (1.15 to 2.72) | −5.74 (−7.09 to −4.39) | 9.62 (8.27 to 10.97) | 15.36 |
| RRMS (n = 61) | 88.2±11.7 | 89.4±13.1 | 0.96 | <0.001 | 1.13 (0.19 to 2.06) | −6.18 (−7.80 to −4.56) | 8.44 (6.82 to 10.06) | 14.62 |
| Healthy Controls (n = 34) | 94.9±11.6 | 98.3±12.8 | 0.96 | <0.001 | 3.39 (2.06 to 4.71) | −4.19 (−6.48 to −1.90) | 10.97 (8.68 to 13.26) | 15.16 |
| TMV** | ||||||||
| All Participants (n = 98) | 7.92±0.47 | 8.31±0.49 | 0.93 | <0.001 | 0.387 (0.349 to 0.424) | 0.013 (−0.052 to 0.078) | 0.761 (0.696 to 0.826) | 0.748 |
| RRMS (n = 63) | 7.78±0.47 | 8.17±0.50 | 0.93 | <0.001 | 0.391 (0.346 to 0.437) | 0.030 (−0.049 to 0.109) | 0.752 (0.673 to 0.831) | 0.722 |
| Healthy Controls (n = 35) | 8.16±0.35 | 8.54±0.39 | 0.86 | <0.001 | 0.379 (0.310 to 0.447) | −1.022 (−0.141 to 0.097) | 0.780 (0.661 to 0.899) | 0.802 |
Abbreviations: OCT: Optical coherence tomography; RNFL: Retinal nerve fiber layer; RRMS: Relapsing remitting multiple sclerosis; TMV: Total macular volume; CI: confidence interval; LOA: limit of agreement.
*All measurements are in µm.
**All measurements are in mm3.