Figure 3. In vivo elimination of MHC-I^neg lymphocytes is NK-cell dependent.

GzmAxB^−/− mice were infected with aSFV and injected at days 2 and 3 with anti-asialo GM1 antibody. At day 3 post-infection, CFSE-labelled target cells were also injected and target cell elimination analysed after 4 hours as in Fig. 1. (A) Proportion of NK1.1⁺ cells in spleen and popliteal lymph nodes of recipient mice after sacrifice. (B) Specific elimination of MHC-I^neg target cells in NK-depleted or non-depleted mice. Data shown are means +/− SD.