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. 2011 Aug 11;6(8):e23200. doi: 10.1371/journal.pone.0023200

Table 4. Continuous renal replacement therapy and outcomes.

Case 1 Case 2 Case 3 Case 4 Case 5 Case 6 Mean ± SD
Type
CVVH or CVVHDF CVVH CVVH CVVHDF CVVH CVVHDF CVVHDF -
Therapy parameters
Blood flow rate (ml/min) 200 180 150 200 180 250 193±33
Effluent rate (ml/kg/h) 34 33 39 22 38 36 34±6
Dialysate rate (ml/h) 0 0 2500 0 2000 500 1250±1215
Replacement fluid rate (ml/h) 1600 2500 2000 2500 2500 2800 2317±436
Filtration fraction (%) 13 30 22 29 17 19 22±7
Initial fluid removal (ml/h) 0 50 0 0 100 0 25±42
Length (days) 5 12 15 1 3 5 7±5
Metformin clearance
Rate of elimination (%/h) 2.7 4.0 1.5 1.6 2.1 2.3 2.4±0.9
Outcomes
ICU length of stay (days) 11 26 17 8 22 9 16±7
Survival to discharge Yes Yes Yes Yes Yes Yes -
Discharge at home Yes Yes Yes Yes Yes Yes -

CVVH, continuous venovenous hemofiltration; CVVHDF, continuous venovenous hemodiafiltration.