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. 2011 Aug 11;7(8):e1002239. doi: 10.1371/journal.pgen.1002239

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A) In 50 µM DNQX, which isolates the ON–bipolar cells, WT and celsr3 mutant eyes have a similar response suggesting that ON-bipolar cells are normal (see Results), and it is ionotropic glutamate responses that are defective. B) The DNQX sensitive curve is obtained by subtracting the DNQX-treated waveform from the untreated response [23]. The isolated DNQX sensitive b-wave element is called b1. The b1 element is larger in celsr3 mutants. C) The WT and celsr3 mutant response is similar in 25 µM picrotoxin, a GABA_A/C inhibitor, suggesting that changes to GABA signaling are causing the increase in the celsr3 mutant b1-wave. Black bar indicates 3 sec. light pulse. Graphs are the average of at least 6 animals.