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. 2011 Aug 11;7(8):e1002229. doi: 10.1371/journal.pgen.1002229

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Kung et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The heatmap representing the transcriptional response of MCF7 (luminal) and MDAMB231 (basal) cells to glutamine deprivation. (B, C). The predictive probability of the amino acid response (AAR) are shown for the luminal (B, p = 0.4, unpaired t-test) and basal (C, p = 0.0016) cancer cell lines grown under normal (4 mM, Q4) and glutamine-deficient (0 mM, Q0) medium. (D, E) The expression of selected canonical amino acid response genes including XBP1 (D) and DDIT3 (E) in MCF7 and MDAMB231 under indicated concentrations of glutamine with real time RT-PCR.