Skip to main content
. Author manuscript; available in PMC: 2012 Feb 11.
Published in final edited form as: Nature. 2011 Jul 20;476(7359):170–175. doi: 10.1038/nature10336

Figure 1.

Figure 1

Building an African American genetic map. (A) HAPMIX detection of crossovers between segments of inferred ancestry is illustrated in a father-mother-child trio. Black segments show inferred crossovers; arrows showtransmission of ancestral crossovers from parent to child, Purple/green segments show de novo events (paternal/maternal origin respectively), corresponding to events identified directly using two additional children (bottom,“Pedigree inferred”).(B) The AA Map localizes five hotspots in a region of the MHC whose positions (blue) were previously mapped by sperm typing1. (C) Comparison of maps shows a hotspot at 33.1Mb in the African-derived AA and YRI maps, but not the deCODE and CEU maps (all maps smoothed to 10kb).