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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Hippocampus. 2011 May 3;22(4):802–813. doi: 10.1002/hipo.20941

Figure 6.

Figure 6

Representative Western blot of the effects of acute cocaine (2.5 mg/kg) on expression of hippocampal ERK1/2 signaling in C57BL/6 male mice. On Test Day (a-b), 24 hr after spatial memory training and drug administration, cocaine (2.5 mg/kg) increased the levels of p90RSK, without affecting pERK1 (p>0.05), pERK2 (αp=0.07), or total (p>0.05) levels of protein when compared to controls (all normalized to GAPDH). Acute cocaine (2.5 mg/kg) in naive C57BL/6 mice (c-d) selectively increased hippocampal pERK2, without affecting pERK1, p90RSK, or total levels of protein (all normalized to GAPDH). VEH, saline-treated animals. *Indicates p<0.05 when compared to controls.