Table 1.
Subject characteristics and FDG-PET regions-of-interest measures by family history group
| NH | PH | MH | |
|---|---|---|---|
| N | 36 | 24 | 36 |
| Age (yrs) | 63(12) | 58(9) | 60(9) |
| Gender (males/females) | 11/25 | 13/11 | 10/26 |
| Education (yrs) | 16(2) | 17(2) | 16(2) |
| Apolipoprotein E ε4 genotype (ε4-/ε4+) | 28/8 | 11/13* | 19/17* |
| Maternal age at subjects’ birth (yrs) | 29(4) | 28(5) | 28(5) |
| Paternal age at subjects’ birth (yrs) | 32(5) | 34(7) | 32(6) |
| Affected parent’s age at onset (yrs) | - | 77(10) | 69(8) |
| Mini Mental State Examination | 29.4(1.2) | 29.7(0.8) | 29.7(0.5) |
| Designs | 6.2(2.2) | 7.4(2.5) | 6.9(1.9) |
| Digit symbol substitution test | 58.0(9.5) | 62.0(9.3) | 56.5(8.6) |
| Object naming | 56.2(4.5) | 52.1(8.1) | 53.9(5.7) |
| Paired Associates delayed recall | 9.9(4.0) | 10.2(2.3) | 8.9(2.9) |
| Paragraph delayed recall | 6.1(2.1) | 6.2(3.1) | 5.9(2.2) |
| Visual recognition test | 13.3(14.7) | 12.5(14.3) | 18.6(11.9) |
| WAIS vocabulary | 67.9(7.8) | 70.6(8.7) | 66.7(9.2) |
Values are means (SD)
*
Different from NH, P<0.05