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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: J Thromb Haemost. 2011 Aug;9(8):1562–1571. doi: 10.1111/j.1538-7836.2011.04394.x

Fig. 6.

Fig. 6

Inhibition of p38 and NF-kappaB pathways mimics the effect of heat exposure on platelet alpha-granule secretion. WPs were preincubated with SB203580 (25 μM), RO1069920 (6 μM) or the combination of both for 10 minutes and then stimulated with thrombin (0.05 U/ml) for 5 minutes. P-selectin was detected by flow cytometry (n=5). vWF, VEGF, and endostatin levels in the supernatants were quantified by ELISA (n=4). Results are expressed as fold increase vs. unstimulated controls. *P < 0.05 vs. unstimulated control; #P < 0.05 vs. thrombin alone.