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Accumulation of a-syn in TH+ neurons. Brain sections were co-stained with anti-TH (2nd Ab with Texas red) and anti-a-syn (2nd Ab with FITC), showing reduced TH+ neurons and aggregated a-syn in remaining TH+ neurons in KO mouse. IP injection of KO mouse with LIGA-20 for 5 weeks attenuated a-syn accumulation while rescuing TH+ neurons
