Fig. 6.

Biochemical analyses. Dissected striata were extracted with 0.4 N HClO₄, spiked with dihydroxybenzylamine as internal standard and subjected to HPLC. (A) Striatal DA and DOPAC, that were significantly reduced in the KO; (B) 5-HT and 5-HIAA, that were not significantly reduced. Data are averages ± SEM; # of animals indicated in (). Statistical significance was determined by Student’s two-tailed t test: * and *** represent P < 0.05 and 0.001, respectively