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Biochemical pathways of DMSP demethylation. 1, DMSP demethylase (DmdA); 2, 5,10-methylene-THF reductase (MetF, E.C. 1.5.1.20); 3, methylene-THF dehydrogenase (FolD, E.C. 1.5.1.5); 4, methenyl-THF-cyclohydrolase (E.C. 3.5.4.9); 5, methionine synthase (MetH, E.C. 2.1.1.13); 6, methionine salvage pathway (multiple enzymes); 7, MMPA-CoA ligase (DmdB); 8, MMPA-CoA dehydrogenase (DmdC); 9, methylthioacryloyl-CoA hydratase (DmdD); 10, acetaldehyde dehydrogenase (E.C. 1.2.1.10).
