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. 2011 May 9;122(2):512–525. doi: 10.1093/toxsci/kfr111

FIG. 4.

FIG. 4.

Role of caspase-9 in deltamethrin-induced apoptosis. Exposure to deltamethrin increased the activation of caspase-9 in a dose- and time-dependent manner (A and B). Inclusion of the caspase-9 inhibitor, Z-LEHD-FMK (50μM), prevented deltamethrin-induced DNA fragmentation (C and D). Data represent mean ± SEM of four individual experiments, each performed in triplicate and expressed as percentage of control. * indicates significantly different from control and # indicate significant differences between deltamethrin-treated cells and deltamethrin plus Z-LEHD-FMK-treated cells (p < 0.05).