Table 1.

Gene induction attributed to nonclassical action of TH.

Gene	Proposed initial TH action	Method	Cell/tissue type	TH	TH concentration	time of TH tx	Ref.
ZAKI4α (RCAN2)	TRβ/PI3K	microarray/real time PCR/Western	primary human skin fibroblasts	T3	2 nM	24 h	[13,9]
HIF-1α a)	TRβ/PI3K	microarray/real time PCR/Western	primary human skin fibroblasts	T3	2 nM	24 h	[28]
HIF-1α b)	αvβ3(S1)/PI3K and αvβ3(S2)/ERK1/2	RT-PCR	U-87 MG	T3 / T4	1 nM / 100 nM	24 h	[23]
PFKP	TRβ/PI3K, target gene of HIF-1α	microarray/real time PCR/Western	primary human skin fibroblasts	T3	2 nM	24 h	[28]
GLUT1	TRβ/PI3K, target gene of HIF-1α	microarray/real time PCR	primary human skin fibroblasts	T3	2 nM	24 h	[28]
MCT4	TRβ/PI3K, target gene of HIF-1α	microarray/real time PCR	primary human skin fibroblasts	T3	2 nM	24 h	[28]
STC-1	TRβ/PI3K, target gene of HIF-1α	microarray/real time PCR	primary human skin fibroblasts	T3	2 nM	24 h	[31]
MCL1	TRβ/PI3K	RT-PCR	HK2, HEK293	T3	100 nM, free	6-24h	[32]
FGF2	MAPK	RT-PCR	ECV304	T4	100 nM	6-48 h	[33]

free = serumfree medium