Figure 3. Expression of Wnt ligands and Wnt signalling in the SVZ and OB.

(A) Bat-gal reporter mice show that canonical Wnt signalling is prominent in the SVZ at P1 but much less apparent in the RMS and OB. (B) Wnt5a is expressed in cortical neurons, hippocampal neurons and OB neurons at this age. (C, D) The two canonical Wnt ligands Wnt3a and Wnt2b are expressed at significant levels only in the fimbrial neuroepithelium (see arrows) at this age, in contact with the CSF space. (E) High-magnification image of the OB showing that Wnt5a is expressed in granule cells and periglomerular cells in the OB. Scale bar in (A) is 400 μm and applies to (A–D), scale bar in (E) is 50 μm.