Figure 2.

Patient Brain MRIs

(A–C) MRIs from patient 1 performed at 1 year of age. (A) T1-weighted image showing a simplified gyral pattern and increased intracranial space with near-normal ventricular size. (B and C) T2-weighted coronal and axial view showing equal involvement of parietal lobes, normal cerebellum, and basal ganglia with delayed myelination.

(D–F) Low-resolution MRIs from patient 2 at approximately 7 months of age. (D) Sagittal T1-weighted view showing a thin but present corpus callosum and normal brain stem. (E) T1-weighted coronal view through the hippocampus showing simplified gyration and hippocampal hypoplasia. (F) T2- weighted view, demonstrating the simplified gyral pattern and normal ventricular size.