IER3IP1 Sequence and Expression in Developing Brain
(A) Schematic representation of human IER3IP1 showing the sequence, the predicted protein domains, and the location of the p.Val21Gly and p.Leu78Pro mutations. Cross-species conservation of IER3IP1 in the areas of the mutations is shown at the bottom of the diagram. Both of the predicted amino acid changes are in a highly conserved area of the gene and in the hydrophobic/transmembrane domains, and they are depicted in red.
(B) Expression of Ier3ip1 at E14.5 days in the whole-mouse embryo (left); zoomed in, in the right panel is the mouse brain, with arrows pointing to increased expression in the ventricular and subventricular zone at the site of neurogenesis.24