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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Kidney Int. 2011 Feb 2;79(10):1090–1098. doi: 10.1038/ki.2010.544

Figure 2. FTY720 and SEW2871 improve renal histology in diabetic nephropathy.

Figure 2

Masson's trichrome staining of kidney sections from normal control rat (a, e), diabetic rat treated with vehicle (b, f), and a diabetic rat treated with FTY720 (c, g) or SEW2871 (d, h) at 9 weeks of the study. Representative photographs show extensive tubular damage with vacuolization (arrows), interstitial fibrosis (blue staining of interstitial collagen), and increased intertubular space (arrowhead) in vehicle-treated diabetic rats and minimal changes in treated animals. Bar = 50 μm.