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. 2011 Aug 1;3:16. doi: 10.3410/M3-16

Figure 2. Schematic representation of Neisseria meningitidis serogroup B (MenB).

Figure 2.

The capsular polysaccharide is a self antigen that cannot be used to make a vaccine. The most abundant antigen is PorA, which is variable and induces only strain-specific protection. A vaccine inducing broad protection was developed using reverse vaccinology to mine the genome and identify less abundant but more conserved antigens such as FHBP (factor H-binding protein), NadA (Neisseria adhesin A), and NHBA (Neisseria heparin-binding antigen).