Table 1.
Effects of MAO inhibitors on behavior of naïve and METH (or d-amphetamine)-challenged rodents.
| Measurement | MAOI | Species, Dose and Injection Schedule | Effecta | Reference |
|---|---|---|---|---|
| Naïve | ||||
| Locomotion | Clorgyline | Rat, 4 mg/kg, ip x 1 d | NC | Segal et al. 1992 |
| Clorgyline | Mouse, 1 mg/kg, sc x 1 d or 5 d | NC | Kitanaka et al. 2005a | |
| Selegiline | Rat, 0.25 mg/kg, sc x 42 d | NC | Timár et al. 1986 | |
| Selegiline | Rat, 1–20 mg/kg, sc x 1 d | NC | Timár et al. 1996 | |
| Selegiline | Rat, 10 mg/kg, ip x 1 d | Increase | Okuda et al. 1992 | |
| Selegiline | Rat, 10 mg/kg, ip x 1 d | Increase | Themann et al. 2002 | |
| Selegiline | Mouse, 0.3 mg/kg, sc x 1 d or 5 d | NC | Kitanaka et al. 2005a | |
| Pargyline | Rat, 10 mg/kg, sc x 24 d | Increase | Barbelivien et al. 2001 | |
| Stereotypy | Selegiline | Rat, 1–10 mg/kg, sc x 1 d | ND | Timár et al. 1996 |
| Selegiline | Rat, 20 mg/kg, sc x 1 d | Increase | Timár et al. 1996 | |
| Behavioral sensitization | Clorgyline | Mouse, 1 mg/kg, sc x 5 d | ND | Kitanaka et al. 2005b |
| Selegiline | Rat, 10 mg/kg, ip x 8 d | Increase | Themann et al. 2002 | |
| CPP index | Clorgyline | Mouse, 0.1–10 mg/kg, sc x 6 d | Increase | Kitanaka et al. 2006 |
| Selegiline | Rat, 1–20 mg/kg, sc x 4 d | ND | Timár et al. 1996 | |
| Selegiline | Mouse, 10 and 25 mg/kg, ip x 5 d | Increase | Wu and Zhu 1999 | |
| # of CAR | Selegiline | Rat, 1–20 mg/kg, sc x 5 d | ND | Timár et al. 1996 |
| DSEb | Selegiline | Rat, 10–30 mg/kg, ip x 1 | Increase | Yasar et al. 1993 |
| After METH (or d-Amphetamine) challenge | ||||
| Hyperlocomotion | Clorgyline | Rat, 4 mg/kg, ip x 1 d | Decrease | Segal et al. 1992 |
| Clorgyline | Mouse, 1 mg/kg, sc x 1 d or 5 d | Decrease | Kitanaka et al. 2005a,b | |
| Selegiline | Mouse, 0.3 mg/kg, sc x 1 d or 5 d | NC | Kitanaka et al. 2005a | |
| Pargyline | Mouse, 50 mg/kg, ip x 1 d | NC | Lew et al. 1971 | |
| Stereotypy | Clorgyline | Rat, 4 mg/kg, ip x 1 d | Increase | Segal et al. 1992 |
| Clorgyline | Rat, 0.1–10 mg/kg, sc x 1 d | NC | Tatsuta et al. 2005 | |
| Clorgyline | Mouse, 0.1 not 1–10 mg/kg, sc x 1 d | Decrease | Tatsuta et al. 2005 | |
| Selegiline | Rat, 0.25–5 mg/kg, sc x 1 d | Decrease | Timár et al. 1993 | |
| Selegiline | Mouse, 0.1, 1 and 10 mg/kg, sc x 1 d | NC | Tatsuta et al. 2005 | |
| Behavioral sensitization | Clorgyline | Mouse, 1 mg/kg, sc x 5 d | Decrease | Kitanaka et al. 2005b |
| CPP index | Clorgyline | Mouse, 0.1–10 mg/kg, sc x 6 d | NC | Kitanaka et al. 2006 |
| DSEb | Selegiline | Rat, 3 and 5.6 mg/kg, ip x 1 | Increase | Yasar et al. 1993 |
| Mortality | Selegiline | Mouse, 2 mg/kg, sc, x 13 d | NC | Grasing et al. 2001 |
| Selegiline | Mouse, 0.02 and 0.2 mg/kg, sc, x 13 d | Decrease | Grasing et al. 2001 | |
This table compares the published effects of MAO inhibitors (MAOI) on naïve and METH-treated mice. CAR: conditioned avoidance responses; CPP: conditioned place preference; DSE: discriminative stimulus effect; NC: no change; ND: not detected; ip: intraperitoneal injection; sc: subcutaneous injection. “Selegiline” means “l-isomer of selegiline” in this table.
Comparison between MAOI- and vehicle-pretreated subjects.
Mice were used after they were trained under a 5-response, fixed ratio schedule of stimulus-shock termination or a 10-response, fixed ratio schedule of food presentation to discriminate between d-amphetamine (1 mg/kg) and saline in a two-lever, conditioning procedure.