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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2011 Jun 2;10(8):1490–1499. doi: 10.1158/1535-7163.MCT-10-1043

Figure 2. Top 1-cleavage complex induction by Genz-644282.

Figure 2

A) Schematic representation of the oligonucleotide substrate containing a single Top1-mediated cleavage site. The positions relative to the Top1 cleavage site [between positions (−3) and (+3)] are indicated. B) Comparisons of Top1-mediated DNA cleavage induced by Genz-644282 and CPT with the oligonucleotide substrate shown in panel A. C) Quantitative analysis of cleavage complexes induced by CPT or Genz-644282 are plotted as a function of compound concentrations.