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Summary of the multiple mechanisms induced by sinomenine. Sinomenine produces the vasorelaxation via NO and PGI2 releasings from endothelium. Also, sinomenine causes the vasorelaxation via modulation of Ca2+ channels and PK-C activity in smooth muscle cells. In addition, β-adrenoceptor stimulation is caused. NOS: nitric oxide synthetase, PK-C: protein kinase C, PGI2 : prostaglandin I2.
