Figure 5.

Bioluminescence imaging (BLI) and positron emission tomography of human ESC-derived teratoma. The photograph and BLI shows teratoma formation by human ESCs at the right flank and tumor formation by a control cell line at the left flank of mice. Specific and prominent uptake of ⁶⁴Cu-DOTA-RGD4 was observed in the teratoma (high integrin α_vβ₃ expression) but not in the control tumor (low integrin α_vβ₃ expression). In contrast, the teratoma had significantly lower uptake of ¹⁸F-FDG and ¹⁸F-FLT than the control tumor. Adapted from [51].