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. Author manuscript; available in PMC: 2011 Aug 12.
Published in final edited form as: Oncogene. 2010 Oct 4;30(2):127–138. doi: 10.1038/onc.2010.456

Figure 2.

Figure 2

Keratins in mammary epithelial cells in vitro and in vivo. (a) K8 immune staining in immortalized mouse mammary epithelial cells (Karantza-Wadsworth and White, 2008) in two-dimensional culture. (b) The mammary gland is a compound tubuloalveolar epithelial cell structure consisting of secretory acini grouped within lobules and draining into intralobular ducts, which in turn drain into interlobular ducts. Lobules are organized into 15–20 lobes emptying into lactiferous sinuses and from there into lactiferous ducts, which open onto the nipple. Ducts (left panel) and acini (right panel) are lined with luminal epithelial cells expressing K8/K18, K19 and K6. These are surrounded by myoepithelial cells, which are characterized by K5, K14 and K17 expression.