Table 2.
IC50 values (the dose (nM) which produces 50% inhibition of growth) of free MTX, MTX-HSA nanoparticles, low, medium and high LHRH targeted MTX-HSA nanoparticles on the LHRH receptor positive T47D cells and LHRH receptor negative SKOV3 cells after 24 h.
| Free MTX | Non Targeted MTX-HSA Nanoparticles | Low LHRH Targeted MTX-HSA Nanoparticles | Medium LHRH Targeted MTX-HSA Nanoparticles | High LHRH Targeted MTX-HSA Nanoparticle | |
|---|---|---|---|---|---|
| T47D cells | 78.23 ± 3.12 | 49.2 ± 2.12 | 19.3 ± 1.98 | 9.12 ± 1.36 | 5.82 ± 1.08 |
| SKOV3 cells | 35.89 ± 1.46 | 15.12 ± 2.19 | 17.64 ± 2.23 | 14.89 ± 2.78 | 14.53 ± 1.46 |