Table 2.
Tumor targeting and normal organ distribution of i
| Time points (h) | |||||
|---|---|---|---|---|---|
| Tissue | 24 | 48 | 72 | 96 | 168 |
| Blood | 6.84 ± 2.30 | 2.28 ± 0.53 | 1.12 ± 0.27 | 0.32 ± 0.12 | 0.08 ± 0.02 |
| Tumor | 21.42 ± 7.67 | 21.12 ± 2.85 | 21.55 ± 6.2 | 16.55 ± 2.35 | 8.01 ± 3.65 |
| Liver | 8.01 ± 1.63 | 4.98 ± 0.98 | 4.66 ± 0.62 | 3.55 ± 0.62 | 3.38 ± 0.67 |
| Spleen | 5.43 ± 1.64 | 3.61 ± 0.87 | 3.96 ± 1.19 | 2.63 ± 1.12 | 2.09 ± 0.80 |
| Kidneys | 13.13 ± 2.34 | 8.27 ± 0.84 | 6.00 ± 1.57 | 5.22 ± 0.94 | 2.66 ± 0.46 |
| Lung | 4.40 ± 1.14 | 2.23 ± 0.39 | 1.79 ± 0.31 | 1.06 ± 0.21 | 0.8 ± 0.26 |
| Heart | 3.57 ± 1.11 | 2.06 ± 0.23 | 1.86 ± 0.30 | 1.20 ± 0.21 | 0.78 ± 0.12 |
| Femur | 2.41 ± 0.48 | 1.78 ± 0.41 | 1.67 ± 0.24 | 1.01 ± 0.24 | 0.75 ± 0.22 |
Athymic mice bearing s.c. LS-174T xenografts were injected with 111In- CHX-A"-panitumumab F(ab')2 (approximately 7.5 μCi). At the indicated time points, the mice (n = 5) were sacrificed by exsanguination; the tumor, blood, and major normal organs were harvested, wet-weighed, and the radioactivity measured. The values represent the average percent injected dose per gram (%ID/g) of tissue along and the standard deviations.