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Immunolocalization of aquaporin 1 (AQP1) and aquaporin 4 (AQP 4). (A, B) AQP4 immunoreactivity (IR) is present in both gray (upper half of image) and white matter (lower half) in an Alzheimer disease + cerebral amyloid angiopathy (AD + CAA) case (A). AQP1 IR in the same patient is localized almost exclusively in subcortical white matter (lower half) (B). In both panels, the pial surface is at top of the image. (Original magnification: 4x).
