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Immunolocalization of aquaporin 1 (AQP1) and aquaporin 4 (AQP 4) in subpial regions of Alzheimer disease + cerebral amyloid angiopathy (AD + CAA) cases. (A, B) There is prominent AQP4 immunoreactivity (IR) in subpial areas (A) and weak AQP1 IR in the corresponding regions from the same patient (B). (C, D) Prominent AQP4 subpial IR is noted in 2 other cases with AD + CAA. (Original magnifications: A-C, 4x; D, 20x).
