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. Author manuscript; available in PMC: 2011 Aug 12.
Published in final edited form as: Epilepsy Res. 2010 Apr 3;90(1-2):39–46. doi: 10.1016/j.eplepsyres.2010.03.005

Figure 2.

Figure 2

Tonic GABAergic inhibition in dentate gyrus granule cells depends on SSADH gene dosage. (A) The holding current was plotted against time and used to estimate the tonic current sensitive to the GABAA receptor antagonist SR95531 (∼100 μM). In this representative WT granule cell, the SR95531 sensitive tonic GABAA current was 5.8 pA. In the granule cell from SSADH KO mouse, the tonic GABAA current was larger and reached 34.0 pA. Cells were clamped at a Vhold of −70 mV. The Gaussian curves (left) represent all-points histograms of the holding current. Medians represent the mean currents, while the deviation correlates with the noise level. After SR95531 application, there is a decrease in the noise level. (B) Histogram showing that the average tonic GABAA receptor-mediated current densities in granule cells depended upon the SSADH gene dosage. The number of cells included were WT (n = 13), HET (n = 12), and KO (n = 7). *P < 0.05; **P < 0.01.