Table 2.
Polymorphic variants in the DRD2 and DRD3 genes genotyped in PEGASUS control subjects
| SNP Name | Location | Minor/Major Allele |
Minor Allele Frequency (%) | ||||
|---|---|---|---|---|---|---|---|
| Non-Hispanic White N=1279 |
Hispanic White N=164 |
Asian N=226 |
African- American N=66 |
||||
| DRD2 | |||||||
| rs1076563 | 5’ | 503 5’ Tr start | T/G | 38.9 | 57.1 | 89.4 | 65.9 |
| rs6279 | exon 8 | 3’ UTR | C/G | 30.8 | 39.6 | 54.1* | 56.2 |
| rs6278 | exon | 3’ UTR | T/G | 15.1 | 20.2* | 36.5 | 9.1 |
| rs273482 | exon | 3’ UTR | C/G | 31.0 | 42.9 | 53.5 | 65.9* |
| rs1800497 | exon | 10 kb exon 8 | T/C | 19.4 | 29.6* | 36.6 | 43.0 |
| rs1799732 | 5’ | −141 5’ exon 1 | Del/C | 9.3 | 18.6 | 13.6 | 39.4 |
| DRD3 | |||||||
| rs6280 | exon | Ser/Gly | G/A | 32.6 | 48.8 | 25.3 | 73.5 |
| rs2134655 | intron | 146 3’ exon 5 | A/G | 27.7 | 21.3 | 29.7* | 8.3 |
*
p-value < 0.01 for Hardy-Weinberg Equilibrium chi-square