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. 2011 Aug 12;6(8):e23308. doi: 10.1371/journal.pone.0023308

Figure 1. Effect of CuZnSOD deficiency and aging on ischemia-induced neovascularization.

Figure 1

A. Representative results of laser Doppler measurements 7 days after hindlimb ischemia in young (Y) and older (O) wild-type (CuZnSOD+/+) and CuZnSOD−/− mice. A color scale illustrates blood flow variations from minimal (dark blue) to maximal (red) values. Arrows indicate ischemic (left) hindlimb. B. Quantification of Laser Doppler perfusion ratios. C–D. Quantification of capillary (C) and arteriolar (D) densities in ischemic muscles harvested at day 7 in the different groups. Data are mean vessels/mm2 ± SEM (n = 7–10/group). *P<0.05 vs. young wild type mice. @P<0.05 vs. old wild type mice. #P<0.05 vs. young CuZnSOD−/− mice.