Table 1. Histopathological alterations of mice lungs exposed to MBS or MSS.
Saline | MBS | MSS | |||||
Criteria | 6.25 µg | 25 µg | 100 µg | 6.25 µg | 25 µg | 100 µg | |
Perivascular infiltration of mononuclear cell | 0 | 1 | 2 | 3a | 2 | 3 | 4a |
Perivascular infiltration of granulocytes | 0 | 0 | 0 | 0 | 1.5 | 0 | 0 |
Peribronchial infiltration of mononuclear cell | 0 | 0a | 1a | 0a | 1b | 1b | 1b |
Thickening of alveolar septa | 0 | 1a | 1a | 2a | 2b | 2b | 3b |
Macrophage accumulation | 0 | 0.5 | 1.5 | 2a | 1.5 | 1 | 2a |
Results are expressed as median scores for each group, graded on a scale from 0 (no alteration) to 5 (severe alterations). Letters represent statistical differences between each dose of MBS and MSS within a same criteria. Six mice per group were analyzed. p<0.05.