Skip to main content
. 2011 Aug 12;6(8):e23669. doi: 10.1371/journal.pone.0023669

Figure 1. Mast cell-deficient Sash mice are highly susceptible to NSAID-induced peptic ulcers.

Figure 1

A. Mean weight data is shown for 13 Sash and 10 wild type (WT) mice exposed to 200 ppm piroxicam in their diet. SEMs ranged from 0.4–1.6% of pre-treatment weight; error bars were omitted for clarity. The rapid weight loss correlates with decreased intake of food and water. Euthanasia for humane reasons was typically required on days 4–6. * indicates p≤0.05 relative to WT mice. Piroxicam-exposed Sash mice demonstrated marked gastric distension by gas and fluid (B, bottom half of panel C) compared with Sash mice not exposed to piroxicam (labeled “control” in panel C). Histologic examination showed ulceration at the gastroduodenal junction (E) of Sash mice, with marked inflammatory cell infiltration and edema that led to gastric outlet obstruction. WT mice (D) do not typically develop ulcers or changes in stomach size with piroxicam exposure.