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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Semin Cell Dev Biol. 2011 Mar 21;22(5):452–459. doi: 10.1016/j.semcdb.2011.03.003

Figure 2.

Figure 2

Three prions, [PSI+], [ISP+], and [NSI+], affect translation fidelity. A, In [PSI+] cells, the majority of Sup35 is sequestered in prion aggregates, resulting in partial read-through of nonsense translation codons, such as TGA in ade1-14. B, In [ISP+] cells, Sfp1 forms nuclear prion aggregates that result in suppression of nonsense read-through in some sup35 and sup45 mutant strains. C, In [NSI+] cells, an unidentified prion protein forms prion aggregates, resulting in nonsense codon read-through, a phenotype similar to that of [PSI+]. Aggregated Sup35 is not implicated in this phenotype.