Table 1.
Summary of the characteristics of known yeast prions.
| Prion | Protein Determinant |
Native function | Amyloid structure |
Curability | Ref | ||
|---|---|---|---|---|---|---|---|
| hsp104Δ | HSP104↑ | GdnHCl | |||||
| [PSI+] | Sup35 | translational termination | yes | yes | yes | yes | [9,16,73,74] |
| [URE3] | Ure2 | Gln3 repressor | yes | yes | no | yes | [2,20,75] |
| [PIN+]/[RNQ+] | Rnq1 | Unknown | yes | yes | no | yes | [7,5,76] |
| [SWI+] | Swi1 | transcriptional regulation | yes | yes | no | yes | [39,42,45] |
| [OCT+] | Cyc8 | transcriptional regulation | N/D | N/D | no | yes | [43] |
| [MCA] | Mca1 | metacaspase homologue | N/D | N/D | yes | yes | [47] |
| [MOT3] | Mot3 | transcriptional regulation | yes | yes | N/D | yes | [45] |
| [GAR+] | Pma1/Std1* | proton pump, glucose signaling | no | no | no | no | [49] |
| [ISP+] | Sfp1 | transcription factor | N/D | no | no | yes | [56] |
| [NSI+] | unknown | unknown | N/D | yes | no | yes | [57] |
*
[GAR+] appears to be propagated by the interaction between two proteins
N/D: not determined
Δ: deletion; ↑: overexpression