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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Behav Pharmacol. 2011 Sep;22(5-6):607–616. doi: 10.1097/FBP.0b013e3283474a6d

Figure 6.

Figure 6

Morphine attenuated tumor-evoked mechanical hyperalgesia. A. Time course of the anti-hyperalgesic effect of morphine (7 µg, i.pl.). A reduction in mechanical hyperalgesia occurred at the earliest time point measured (15 min) and persisted through 1.5 h. *Different from vehicle at respective time point at p<0.01 (n=6–7 mice/group; two-way ANOVA with Bonferroni’s analysis). Intraplantar injection of morphine contralateral to the tumor did not modulate hyperalgesia in the tumor-bearing paw (□). B. The anti-hyperalgesic effect of morphine was dose-dependent with an ED50 of 2.92 µg (95% CI: 1.9 to 5.4 µg). Dose was plotted on a log scale.