Fig. 6.
Age-dependent DA signals in control (Nurr1 +/+) mice aged 3–6 months and 15–23 months. (A) The peak amplitude of the DA signal evoked by 1p (left most data points in each panel) or train stimulation (5p at 5–80 Hz) was significantly reduced in the 15–23 month old mice compared to the 3–6 month group (n = 19, 31; * p < 0.05). (B) The area-under-curve of the DA signals from control mice aged 15–23 months was not different from the 3–6 month group. (C) The normalized DA area (train evoked DA signal relative to the 1p evoked DA signal) was increased in the 15–23 month old mice compared to the 3–6 month old mice (* p < 0.05).