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Genistein inhibited the capacity of CSC-self-renewal in primary pancreatospheres of AsPC-1-control and AsPC-1-FoxM1 cells after 1 week of treatment (A) and secondary pancreatospheres of FoxM1 over-expressing AsPC-1 cells after 1 and 3 weeks of treatment (B,C). Secondary pancreatospheres were generated by desegregations of primary pancreatospheres using accutase solution, as described in the Materials and Method section.
