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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Neurochem. 2011 May 25;118(5):879–890. doi: 10.1111/j.1471-4159.2011.07296.x

Figure 6.

Figure 6

APP processing is unaltered in DRM fractions of Fyn knock-out mice. A. Endogenous mouse Aβ1–40 levels were measured in DRM and pellet fractions from wild-type or Fyn knockout mice. There was no significant difference in Aβ1–40 in either the DRM or pellet fractions in Fyn knock-out mice compared to wild-type mice. There was a significant increase in Aβ1–40 levels in the pellet fraction compared to the DRM fraction of both wild-type (18%, p<0.05, n=5) and Fyn knock-out mice (30%, p<0.01, n=5). B. DRM and pellet fractions from wild-type and Fyn knock-out mice were Western blotted for APP CTF, BACE1, Presenilin-1, and Flotillin. Flotillin localized to the DRM fraction, while APP CTF, BACE1, and Presenilin-1 were almost exclusively localized to the non-DRM fraction.