Table 1.
Metabolites identified whose expression ratio varied at least 10% in all three independent experiments, in the results without and with Vitamin K pre-incubation
| Name | Retention time (min) | Warfarin | Warfarin + Vitamin K | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Ave S:C (SD) | p (S:C) | Ave R:C (SD) | p (R:C) | Ave S:V (SD) | p (S:V) | Ave R:V (SD) | p (R:V) | ||
| l-lactic acid | 10.04 | 0.76 ± 0.07 | 0.013 | 0.68 ± 0.18 | 0.045 | 0.67 ± 0.08 | 0.009 | 0.75 ± 0.07 | 0.0112 |
| Glycine | 14.38 | 1.56 ± 0.16 | 0.013 | 1.67 ± 0.03 | 3E-04 | 1.49 ± 0.09 | 0.005 | 1.51 ± 0.07 | 0.0029 |
| l-valine | 15.52 | 1.44 ± 0.05 | 0.002 | 1.31 ± 0.13 | 0.049 | 1.43 ± 0.04 | 0.001 | 1.30 ± 0.05 | 0.0043 |
| l-serine | 20.59 | 0.78 ± 0.03 | 0.002 | 0.86 ± 0.03 | 0.009 | 0.67 ± 0.07 | 0.006 | 0.75 ± 0.07 | 0.0131 |
| l-threonine | 21.47 | 1.15 ± 0.05 | 0.018 | 1.11 ± 0.07 | 0.055 | 1.19 ± 0.06 | 0.018 | 1.16 ± 0.10 | 0.0575 |
| 5-oxoproline | 25.88 | 1.61 ± 0.10 | 0.005 | 1.32 ± 0.04 | 0.003 | 1.46 ± 0.06 | 0.003 | 1.45 ± 0.11 | 0.0093 |
| l-glutamate | 28.66 | 0.77 ± 0.06 | 0.011 | 0.74 ± 0.11 | 0.027 | 0.76 ± 0.04 | 0.004 | 0.75 ± 0.06 | 0.0092 |
| l-glutamine | 33.14 | 1.84 ± 0.06 | 9E-04 | 1.75 ± 0.08 | 0.002 | 1.73 ± 0.14 | 0.006 | 1.69 ± 0.17 | 0.013 |
| Glucuronic lactone | 34.34 | 0.91 ± 0.14 | 0.07 | 0.73 ± 0.02 | 0.032 | 0.87 ± 0.03 | 0.009 | 0.59 ± 0.08 | 0.0058 |
| Arachidonic acid | 47.12 | 1.40 ± 0.05 | 0.003 | 1.18 ± 0.07 | 0.025 | 1.41 ± 0.07 | 0.025 | 1.10 ± 0.07 | 0.1289 |
In the left panel, C control group, S S(−) warfarin incubated group, R R(+) warfarin incubated group. Ave S:C the average ratio of S(−) warfarin incubated group compared to control group in the three times of the experiment, Ave R:C the average ratio of R(+) warfarin incubated group compared to control group in the three times of the experiment. SD standard deviation of the three ratio; p(S:C) or p(R:C) P values calculated from Student’s t-test. In the right panel, V vitamin K treated group, S vitamin K incubated then S(−) warfarin incubated group, R vitamin K incubated then R(+) warfarin incubated group. Ave S:V the average ratio of S(−) warfarin incubated group compared to vitamin K treated group in the three times of the experiment; Ave R:V the average ratio of R(+) warfarin incubated group compared to vitamin K treated group in the three times of the experiment. SD standard deviation of the three ratio; p(S:V) or p(R:V) P values calculated from Student’s t-test