. Author manuscript; available in PMC: 2011 Nov 1.

Published in final edited form as: Mucosal Immunol. 2011 Feb 9;4(3):279–287. doi: 10.1038/mi.2011.3

Table 1.

Different interactions between MOMP and MPT alter the cell death modality

Scenario	I	II	III	IV
	MOMP dependent on MPT	MOMP independent of MPT	MPT dependent on MOMP	MPT independent of MOMP
Example	Induction of apoptosis in cells undergoing MPT due to oxidative stress ³²	Induction of cytochrome c release from the mitochondria in staurosporine-treated CEM cells does not affect MPT ³⁴	Inner mitochondrial membrane damage caused by caspase-3³⁵	Granzyme A damage of the inner mitochondrial membrane ³⁶
Outcome	Necrosis	Apoptosis	Necrosis	Necrosis

Abbreviations: MOMP, mitochondrial outer membrane permeabilization; MPT, mitochondrial permeability transition.