Table 3.
Areas of activation for the contrasts of all task conditions minus fixation
| Region | Cluster size | t(14) | MNI coordinates |
||
|---|---|---|---|---|---|
| x | y | z | |||
| Control | |||||
| Occipital/inferior parietal/superior parietal/inferior temporal/middle temporal/cerebellum | 45 755 | 16.91 | −26 | −62 | 42 |
| Right middle frontal (BA9) | 121 | 6.08 | 50 | 34 | 36 |
| Anterior cingulate (BA32) | 162 | 5.97 | 12 | 22 | 38 |
| Right insula (BA13) | 565 | 5.91 | 20 | 30 | 6 |
| Right superior frontal (BA10) | 34 | 5.38 | 40 | 60 | −2 |
| Right middle frontal/precentral (BA6) | 109 | 4.98 | 36 | 4 | 62 |
| Right amygdala | 57 | 4.62 | 30 | 0 | −12 |
| Right middle frontal (BA10) | 13 | 4.62 | 34 | 58 | 26 |
| Right middle frontal (BA6) | 19 | 4.44 | 24 | −12 | 40 |
| Autism | |||||
| Occipital/inferior parietal/superior parietal/inferior temporal/middle temporal/cerebellum | 43 906 | 16.53 | −34 | −56 | −32 |
| Left middle frontal/precentral (BA6/9) | 2536 | 9.26 | −34 | 6 | 64 |
| Right middle frontal/precentral (BA6/9) | 1282 | 7.01 | 34 | 4 | 66 |
| Posterior cingulate | 357 | 6.14 | −2 | −36 | 24 |
| Right superior frontal (BA10) | 42 | 5.51 | 40 | 60 | 2 |
| Right inferior frontal (BA45) | 72 | 5.19 | 56 | 32 | 28 |
| Left superior frontal (BA10) | 18 | 4.75 | −20 | 60 | 0 |
| Cerebellum | 18 | 4.37 | 4 | −54 | −26 |
| Right insula (BA13) | 26 | 4.33 | 36 | 26 | −4 |
| Right middle frontal (BA46) | 22 | 4.32 | 32 | 34 | 24 |
| Right caudate | 13 | 4.30 | 14 | 16 | 20 |
| Right middle frontal (BA10) | 13 | 4.18 | 34 | 50 | 16 |
| Left caudate | 26 | 4.10 | −10 | 12 | 24 |
| Left postcentral | 10 | 3.92 | −54 | −18 | 22 |
| Autism > Control | |||||
| Right middle frontal/precentral/postcentral (BA6/4/3) | 467 | 4.67 | 44 | −18 | 60 |
| Right postcentral (BA5) | 45 | 4.41 | 44 | −44 | 60 |
| Right precuneus (BA19) | 12 | 4.04 | 22 | −86 | 38 |
| Post cingulate | 28 | 3.97 | −6 | −36 | 28 |
| Right posterior middle temporal (BA21) | 11 | 3.92 | 58 | −48 | −8 |
| Right middle frontal (BA6) | 64 | 3.92 | 38 | 10 | 36 |
The threshold for significant activation was P < 0.001 for a spatial extent of at least 10 voxels, uncorrected for multiple comparisons. Region labels apply to the entire extent of the cluster. T-values and MNI coordinates are displayed for the peak activated voxel in each cluster. For group comparison, there was no area that showed greater activation for the control group than the autism group.